Howes JB, Tran D, Brillante D, Howes LG. The effect of isoflavone phytoestrogens in relieving hot flushes in Peruvian post menopausal women. Some medications that are changed by the liver include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s10549-020-05534-4. There is disagreement among researchers about the efficacy of black cohosh to relieve menopause symptoms. Breast Cancer Res 2004;6:R170-R179. View abstract. It’s used to make an herbal supplement that may have some immune-boosting and positive hormonal effects, especially for postmenopausal women. Phytoestrogens for menopausal vasomotor symptoms. [3] The leaves are alternate, trifoliate (with three leaflets), each leaflet 15–30 mm (0.6–1.2 in) long and 8–15 mm (0.3–0.6 in) broad, green with a characteristic pale crescent in the outer half of the leaf; the petiole is 1–4 cm (0.4–1.6 in) long, with two basal stipules that are abruptly narrowed to a bristle-like point. Title 21. There is some early evidence that red clover might help relieve cyclic breast pain and tenderness. View abstract. Unger M, Frank A. Nelson HD, Vesco KK, Haney E, et al. Knight DC. Climacteric 1999;2:79-84. (check all that apply), What factors are most important to you? Effect of genistein and raloxifene on vascular dependent platelet aggregation. 1999;10(8):607-615.

Lipovac, M., Chedraui, P., Gruenhut, C., Gocan, A., Kurz, C., Neuber, B., and Imhof, M. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Taking red clover along with some medications that are broken down by the liver can increase the effects and side effects of some medications. These include black cohosh and herbal teas. The red clover plant actually belongs to the legume plant family (just like peanuts and beans), which is why animals often graze on it in the wild. View abstract. J Nutr 2004;134:1759-64. Lancet 2000;355:163-4. Red clover might decrease how quickly the liver breaks down some medications. Blakesmith SJ, Lyons-Wall PM, George C, et al. CONDITIONS OF USE AND IMPORTANT INFORMATION: View abstract. Janssen K, Mensink RP, Cox FJ, et al. It’s also important to let your doctor know about any herbal supplements you take and questions that you have. Some medications are changed and broken down by the liver. Taking red clover along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Menopause 2009;16:1167-77. Endocrine Soc 82nd Ann Mtg, Toronto, CAN 2000;Jun 21-4:abstract 2359. Red clover is also a source of many valuable nutrients including calcium, chromium, magnesium, niacin, phosphorus, potassium, thiamine, and vitamin C. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with RED CLOVER.

Menopause.Int.

Peterson, G. and Barnes, S. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study. Atkinson C, Oosthuizen W, Scollen S, et al. van de Weijer and Barentsen R. Isoflavones from red clover (Promensil®) significantly reduce hot flashes compared with placebo. The in vivo effect of red clover diet on ventral prostate growth in adult male mice. Today, isoflavone extracts from red clover are most often used as dietary supplements for menopausal symptoms, high cholesterol, or osteoporosis. View abstract.

Weak and brittle bones (osteoporosis). It’s known scientifically as Trifolium pratense. But not all research agrees. Swelling (inflammation) of the main airways in the lung (bronchitis). Gerber G, Lowe FC, Spigelman S. The use of a standardized extract of red clover isoflavones for the alleviation of BPH symptoms. View abstract. Most research shows that taking red clover extracts by mouth for 3 months to a year does not seem reduce low-density lipoprotein (LDL or "bad") cholesterol or increase high-density lipoprotein (HDL or "good") cholesterol in women who have moderately elevated cholesterol levels. Red clover's constituents are thought to stimulate the immune system. The effects of isoflavones derived from red clover on vasomotor symptoms and endometrial thickness. Poster presented at: The Endocrine Society's 83rd Annual Meeting (2000). Red clover contains coumestrol, a phytoestrogen. It’s important to follow the dosing directions on supplements exactly, since they are manufactured by a variety of companies. Diabetes Obes Metab 2003;5(5):325-332. A. Phytother Res 2020 Mar 12. doi: 10.1002/ptr.6650. View abstract. Anti-androgenic action by red clover-derived dietary isoflavones reduces non-malignant prostate enlargement in aromatase knockout (ArKo) mice. View abstract. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. Red clover contains isoflavones, a type of phytoestrogen. This P, De La Rochefordiere A, Clough K, et al. The COVID-19 outbreak is an emerging, rapidly evolving situation. Early research shows that applying a combination product containing red clover flower extract might increase hair growth in people with hair loss. Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology. Climacteric 1999;2:85-92.. View abstract. Anderson JW, Johnstone BM, Cook-Newell ME. Tice JA, Ettinger B, Ensrud K, et al. We encourage you to discuss any decisions about treatment or care with your health care provider. Atkinson C, Compston JE, Day NE, et al. Red clover. J Clin Endocrinol Metab 1999;84:4017-24. Meta-analysis of the effects of soy protein intake on serum lipids. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Imhof M, Gocan A, Reithmayr F, et al. As with your research for red clover, do your research on these as well as teas people take medicinally, like ginseng tea and dong quai tea. Hum.Reprod.Update. The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of postmenopausal women with mild to moderate hypercholesterolemia. Eur J Clin Nutr 2004;58(1):173-179. Shulman, L. P., Banuvar, S., Fong, H. H., and Farnsworth, N. R. Discussion of a well-designed clinical trial which did not demonstrate effectiveness: UIC center for botanical dietary supplements research study of black cohosh and red clover.

This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Manganese and chronic hepatic encephalopathy. JAMA 2006;295:2057-71. Taking red clover along with estrogen pills might decrease the effects of estrogen pills. for menopausal symptoms. Cochrane.Database.Syst.Rev.
2010;94(3):997-1007. [4], The red clover is native to Europe, Western Asia, and northwest Africa, but it has been naturalized in other continents, like North and South America. Menopause 2009;16:1156-66. Due to its coumarin derivatives, T. pratense should be used with caution in individuals with coagulation disorders or currently undergoing anticoagulation therapy. Online ahead of print. Electronic Code of Federal Regulations. concerns about traditional hormone replacement therapy, Research and the usefulness of red clover for menopause. Red clover is a flowering plant and, like lentils and beans, a type of legume.

Red clover may interact with certain medications. View abstract. Friedman, J. It has a deep taproot which makes it tolerant to drought and gives it a good soil structuring effect. A red clover (Trifolium pratense) phase II clinical extract possesses opiate activity. Plasma uptake of manganese as affected by oral loads of manganese, calcium, milk, phosphorus, copper, and zinc. There’s no conclusive evidence indicating that it’s beneficial, but several small studies indicate that it may provide relief for some women. Baber R, Clifton Bligh P, Fulcher G, et al. The flowers are used to make medicine. Uncontrolled Blood Sugar: How Dangerous Is It?
Hormone Replacement Therapy (HRT): Is It Right for You? for Red Clover. View abstract. Gerber G, Lowe FC, and Spigelman S. The use of a standardized extract of red clover isoflavones for the alleviation of BPH symptoms. Baber RJ, Templeman C, Morton T, et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. This information may not fit your specific health circumstances. Umland EM, Cauffield JS, Kirk JK, et al. View abstract. [10][11] There is no evidence in the human trial literature that red clover has been tested for effects on cough, lymphatic system or cancer prevention/treatment.

View abstract. Setchell KD, Gosselin SJ, Welsh MB, et al.

J Obstet Gynaecol Res 2009;35(6):1091-1095. Part 182 -- Substances Generally Recognized As Safe. A., Leinster, S. J., and Cassidy, A. A review of the clinical effects of phytoestrogens. Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis. Hodgson JM, Puddey IB, Beilin LJ, et al.

Natural Medicines Web site. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind). View abstract. Effect of isoflavones on lipids and bone turnover markers in menopausal women. View abstract. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index.

J Am Coll Nutr 1991;10:38-43. The appropriate dose of red clover depends on several factors such as the user’s age, health, and several other conditions. The Endocrine Society's 82nd Annual Meeting 2000;82:2359. Maki PM, Rubin LH, Fornelli D, et al. J.Ethnopharmacol. View abstract. Lipovac M, Chedraui P, Gruenhut C, et al. View abstract. The effect of an isoflavone extract (PO81) on serum lipids, forearm bone density and endometrial thickness in postmenopausal women [Abstract]. Lambert MNT, Thorup AC, Hansen ESS, Jeppesn PB. Tamoxifen (Nolvadex) is used to help treat and prevent these types of cancer. Jeri AR. Myers SP, Vigar V. Effects of a standardized extract of Trifolium pretense (Promensil) at a dosage of 80mg in the treatment of menopausal hot flushes: a systematic review and meta-analysis. The effects of isoflavone phytoestrogens on bone: preliminary results from a large randomized controlled trial.


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